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Scientific Software Services :: Bioinformatics :: Proteomics :: SimGlycan®

SimGlycan® #309

SimGlycan® predicts the structure of glycans and glycopeptides using mass spectrometry data. SimGlycan® accepts the experimental MS/MS data generated by a mass spectrometer, matches them with its own database of theoretical fragments and generates a list of probable candidate structures.

Each structure is scored to reflect how closely it matches your experimental data. Other biological information for the probable glycan structures such as the glycan class, reaction, pathway and enzyme are also made available for easy reference.

SimGlycan® Home

SimGlycan® Features

-Protein Glycosylation

-Post-Translational Modification

-Annotate Mass Spectra

-Draw Glycans

-Get Ranked Results

-Enterprise Edition

Glycan & Glycopeptide MS/MS data analysis tool

SimGlycan® is an innovative glycan and glycopeptide MS/MS data analysis tool. SimGlycan® predicts the glycan structure, scores it and generates a list of probable glycans that closely match the experimental MS profile saving you hours of laborious glycan analysis work. For glycopeptide analysis, SimGlycan® identifies the peptides along with associated glycan structures, using the mass from enzymatically cleaved glycopeptides or precursor ion m/z values. MS/MS data analysis can be performed for a selected glycopeptide to check its proximity with the experimental data. No information regarding the peptide sequence or peptide mass is needed for this analysis.

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Glycan & Glycopeptide MS/MS Data Analysis for Studying Glycosylation

Protein Glycosylation, which is a key post-translational modification, is the result of addition of a glycan to a peptide sequence. Glycopeptides are known to exhibit multiple biological functions. In order to identify distinct functional properties for defined structural features, detailed information on the respective glycan moieties is essential. In order to understand all these phenomena, glycosylation analysis is an area of growing interest. Glycans have also been found to participate in many biological processes including embryonic development, inter and intracellular activities, coordination of immune functions, pathogens homing on their host tissues, cell division processes and protein regulations and interactions.

Glycoprotein glycosylation analysis has since long been a challenging task for biochemists. SimGlycan® assists in predicting the structure of a glycan or glycopeptide from the MS/MS data acquired by mass spectrometry. It supports MS/MS profiles of both glycopeptides and released glycans with different chemical derivatives such as permethylation, and various reducing terminal modifications. These profiles can be uploaded in SimGlycan® using standard file formats or directly from mass spectrometer raw file formats from Applied Biosystems (AB Sciex TOF/TOF 5800, the AB SCIEX 4800 Plus MALDI TOF/TOF™ Analyzer, the AB SCIEX 4000 QTRAP® System, and the AB SCIEX QSTAR® Elite System) and Bruker Daltonics (maXis UHR-TOF, APEX, micrOTOF, micrOTOF-Q and esquire series).

SimGlycan® matches the experimental MS profiles with its own theoretical fragmentation database and generates a list of probable candidate glycan structures. Each structure is scored based on how closely it matches the experimental mass spectrometry data. Additional known biological information for the structures such as glycan class (N-Linked, O-Linked, heparin, lipopolysaccharide etc), reaction, pathway and enzyme is displayed, saving the time needed to retrieve this information from several resources. The predicted glycan structure along with its biological information facilitates glycosylation analysis, which in turn assists glycopeptide characterization.

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SimGlycan® Enterprise Edition

An Enterprise Edition of SimGlycan® is now available. If you are working with a private custom database or with proprietary data, the enterprise edition is the secure tool you are looking for to resolve novel glycans. You can add to or delete glycan structures from the database or create your own sub-database for narrowing down the search, right from the convenience of your workstation. Structural information for multiple glycans can be stored in a single file and added to the database, saving time.

When you buy the Enterprise Edition, you get:
- SimGlycan® client supported on Windows.
- A Smart Updater for both, the client and the database.
- SimGlycan® database and a database search engine supported on a Windows server.
- A user manager and backup system.
- Setup for 3 users. For additional users, please inquire.
- Unlimited technical support.

If you are interested to check out SimGlycan's functions by yourself, download a Demo Version
of SimGlycan here: Demo For Windows

System Requirements

For Windows

Required

Recommended

CPU	Pentium-III 800 MHz	Pentium-IV 2.6 GHz
RAM	1 GB of available RAM	2 GB of available RAM
Hard Disk Drive Space	200 MB of available hard disk	500 MB of available hard disk
Screen Resolution	800 X 600	1024 X 768

Platforms supported for Windows: 98/2000/ME/XP/Vista/Windows 7

Pricing

SimGlycan® Pricing & Packages

License Type	Commercial	Academic
Single User License	$ 9.985,00 NOW $ 9.485,75	Contact Us!
SimGlycan® Enterprise Edition	Contact Us!	Under Request

NOTE: If you want to purchase SimGlycan Academic License(s) or <3 Licenses with Volume Discount please contact us!

Details

Price: $9,485.75 (€ 8,537.18)

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